Follow Us:Respiratio 2017; 7 (1-2): 1-8
SOLITARNI FIBROZNI TUMOR PLEURE – PRIKAZ SERIJE SLUČAJEVA
I PREGLED LITERATURE
SOLITARY FIBROUS TUMOR OF THE PLEURA –SERIES OF CASES AND REVIEW OF THE
LITERATURE
Aleksandra Lovrenski¹, Ivana Jeličić², Dragana Tegeltija³, Miloš Koledin4, Milorad Bijelović4, Milana Panjković¹
¹Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Serbia
²Department for Pathology, General Hospital, Vrbas, Serbia
³Center for Pathology, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia
4Clinic for Thoracic Surgery, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia
Original Research
Naučni članak
SAŽETAK:
Uvod: Solitarni fibrozni tumor pleure (SFTP) je redak, spororastući primarni tumor
pleure koji vodi poreklo od mezenhimalnih ćelija u submezotelnom sloju pleure.
Cilj: Analiza 18 pacijenata sa SFTP sa akcentom na demografske, kliničko-morfološke, histološke i imunohistohemijske karakteristike ove neoplazme, naročito u diferencijaciji benignih od malignih formi.
Metode: Sprovedena je retrospektivna analiza kliničkih podataka 18 pacijenata sa patohistološki dijagnostikovanim SFTP u desetogodišnjem periodu na Institutu za plućne bolesti Vojvodine.
Rezultati: Prosečna starost pacijenata bila je 54 godine. 61.1% pacijenata bilo je ženskog, a 38.9% muškog pola. 44,4% pacijenata bili supušači. Najčešće kliničke manifestacije bile su bol u hemitoraksu (44,4%), kašalj (38.8%) i opšti infektivni sindrom (22,2%). Tumor je bio lokalizovan u desnom hemitoraksu u 61.2% pacijenata, a kod 38.8% u levom. Najmanji dijametar tumora bio je 2 cm, a najveći 15 cm. U jednom slučaju SFTP se prezentovao kao maligni tumor, a u jednom slučaju kao „borderline“ tumor nepredvidivog biološkog ponašanja usled prisustva nekroze, povećane celularnosti i veličine od 13 cm. Vimentin, CD34 i bcl-2 su se pokazali kao pouzdana pozitivna, a CD31, EMA, dezmin and panCK kao pouzdana negativna antitelau dijagnozi ovog tumora.
Zaključak: Granica između benignih i malignih SFTP nije jasno definisana, te se u postavljanju konačne dijagnoze i terapijskog postupka, kao i predviđanju toka bolesti moraju uključiti svi dostupni demografski, klinički, morfološki i imunohistohemijski podaci.
Ključne reči: solitarni fibrozni tumor, pleura, dijagnoza.
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Submitted: April 10th, 2017
Accepted: May 10th, 2017
Aleksandra Lovrenski,
Put doktora Goldmana 4,
21204 Sremska Kamenica,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.