Follow Us:Respiratio 2023, 13 (1-2): 20-28
ZNAČAJ PRIDRUŽENOG RINITISA NA TEŽINU I EGZACERBACIJE HRONIČNE OPSTRUKTIVNE BOLESTI PLUĆA
Maja Bogdan
1,2, Biljana Zvezdin1,2, Violeta Kolarov1,2, Lidija Vrtunski-More2, Jelena Papović 2
Original Research
Naučni članak
Uvod: Koncept ujedinjene bolesti disajnih puteva prepoznat je pre više decenija, kod pacijenata sa astmom. Nedavna istraživanja su ukazala na prisustvo i značaj simptoma rinitisa kod obolelih sa hroničnom opstruktivnom bolešću pluća.
Cilj: Cilj istraživanja bio je da se proceni uticaj simptoma rinitisa na težinu HOBP i pogoršanja.
Materijal i metode: U prospektivnu studiju uključeno je 49 pacijenata, 24 (48,98%) osobe ženskog i 25 (51,02%) muškog pola, prosečne starosti 66,49±7,461 godina. Težina HOBP-a određena je spirometrijskim parametrom FEV1%. Za procenu izraženosti simptoma HOBP-a korišćen je CAT upitinik (COPD Assessment Test). Analizom krvne slike verifikovan je broj eozinofila, upitnikom SNOT-22 (Sino-nasal Outcome Test) prisustvo simptoma rinitisa.
Rezultati: Simptomi rinitisa utvrđeni su kod 75,51% (37) pacijenata. Uočena je statistički značajna razlika u ukupnom skoru SNOT-22 upitnika, rinološkom, ekstranazalnom/rinološkom i slušnom/facijalnom domenu ovog upitnika i krvnoj eozinofiliji u odnosu na prisustvo simptoma rinitisa (p<0,05). Korelacionom analizom potvrđena je statistički značajna povezanost CAT i SNOT-22 upitnika(r=0,001; p<0,05), krvne eozinofilije i slušnog/facijalnog i psihološkog domena SNOT-22 uputnika i njegovog ukupnog skora (r=0,05; r=0,024; r=0,011; p<0,05). Statistički značajna povezanosti uočena je i između ekstranazalnog rinološkog domena SNOT-22 upitnika i broja hospitalnih egzacerbacija (r=0,038; p<0,05), kao i eozinofilije i broja hospitalnih pogoršanja (r=0,019; p<0,05). Povezanost FEV1% i SNOT-22 upitnika nije dokazana (r=0,183; p>0,05).
Zaključak: Simptomi rinitisa značajno utiču na izraženost simptoma hronične opstruktivne bolesti pluća i broj hospitalnih pogoršanja. Krvna eozinofilija značajno utiče na simptome rinitisa i povećava rizik od hospitalnih pogoršanja.
Ključne reči: rinitis; HOBP, eozinofilija; pogoršanje; CAT; SNOT-22
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1 Medicinski fakultet Novi Sada, Univerzitet u Novom Sadu, Srbija
2 Institut za plućne bolesti Vojvodine, Sremska Kamenica, Srbija