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Respiratio 2019; 9 (1-2): 77-81

POUZDANOST PROCJENE PRISUSUSTVA LIMFOVASKULARNE
INVAZIJE KOD PLUĆNOG ADENOKARCINOMA NA OSNOVU
PREOPERATIVNE VELIČINE TUMORA


RELIABILITY OF LYMPHOVASCULAR INVASION ASSESSMENTS IN PULMONARY
ADENOCARCINOMA BASED ON THE PREOPERATIVE TUMOR SIZE


Kemal Grbić, Mirko Stanetić, Slavko Grbić

Original research

Naučni članak

doi: 10.26601/rsp.aprs.19.5

 

Sažetak:
U trenutno važećoj klasifikaciji tumora pluća uveden je pojam “invazivnog adenokarcinoma”
prema stepenu agresivnosti istog. Prisustvo limfovaskularne invazije u tumoru je jedan od takvih
atributa i parametar je očekivano lošeg toka bolesti.

Cilja rada je procjeniti prisustvo limfovaskularne
invazije kod plućnog adenokarcinoma na osnovu preoperativne veličine tumora.

Materijal i metode: U
istraživanje je uključen 261 pacijent operativno tertiran zbog dokazanog adenokarcinoma pluća. U
istraživanje su uključeni samo pacijenti sa decidnom preoperativnomveličinom tumora (cT=mm.) i
limfovaskularnim statusom (LVI) u plućnom resektatu.

Rezultati: Prisutnost LVI, spolna distribucija,
distribucija veličine tumora detreminirana CT-om, te starosna dob između muških i ženskih ispitanika u
ispitivanom uzorku bila je statistički signifikantna (p<0,05). Veličina tumora se pokazala kao značajan
marker pojave LVI u resektatu sa senzitivnošću od 90,9%, specifičnosti 93,5%; PPV = 97,8%; NPV =
76,3%. Cut off vrijednost veličine tumora je iznosila 4,5 cm, a AUK=0,945 (IP 0,905-0,985; p<0.001)
Logističkom regresijom je utvrđeno da je preoperativna veličina tumora nezavisni pozitivni prediktor
pojave limfovaskularne invazije kod adenokarcinoma pluća (OR=7,302; IP=4,303-12,392).

Zaključak:
Preoperativne veličina tumora je statistički značajan marker pojave limfovaskulaarne invazije kod
plućnog adenokarcinoma.


Ključne riječi
: adenokarcinom pluća, veličina tumora, limfovaskularna invazija

Full Article (PDF)

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Corresponding author:
Kemal Grbić
Clinic for Thoracic Surgery, Clinical Center University of Sarajevo
Bolnička 25. 71000 Sarajevo, Bosnia and Herzegovina
Tel. 061 790 994, 033 297 238
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

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